The attractive tenet that recruitment and activation of brown adipose tissue You Can’t Scare Me My Mom Is A Crazy Nurse Anger Issues Serious Dislike Stupid People Shirt could counteract the development of obesity and its comorbidities in humans has been experimentally corroborated mainly by experiments demonstrating that background (exempt from thermal stress) become more obese when fed a high-fat diet. However, concerns may be raised that this outcome of ablation is restricted to this very special inbred and particularly obesity-prone mouse strain.
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Clearly, it is thus of importance to examine to which degree the obesity-inducing effect of ablation is a phenomenon also observable in strains that do not readily become obese. A corresponding question is whether is the only mediator of diet-induced thermogenesis or whether other mechanisms are present in other less obesity-prone strains. Evidently, such data are important to allow for possible translation of effects to human conditions.
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As metabolic effects of restricted to a single obesity-prone mouse strain would hardly be transferable to humans. Therefore, we have examined to which degree ablation has similar metabolic effects in a mouse strain known to be obesity resistant: the strain. For this, male or mice and corresponding knockout mice were fed chow or a high-fat or a cafeteria diet for 4. The absence of augmented obesity (weight gain, body fat mass, %body fat, fat depot size).
In high-fat diet- and cafeteria-fed mice, with a similar or lower food intake, indicating that, when present, indeed decreases metabolic efficiency. Increased obesity was due to a decrease in energy expenditure. The consumption of a high-fat or cafeteria diet increased total protein levels in wild-type mice, and correspondingly, high-fat diet and You Can’t Scare Me My Mom Is A Crazy Nurse Anger Issues Serious Dislike Stupid People Shirt cafeteria diet-fed mice demonstrated increased norepinephrine-induced oxygen consumption.