Because if you’re using human cells you have a lower attrition rate of PhI failures due to misleading data from irrelevant animal models with significantly different physiologies from humans. Yes, there is the problem of differing physiologies… In vitro cell, culture models do not mimic the intact organ systems. I agree Petit Frère Même Si Tu Es Plus Grand Que Moi N’oublie Pas Je Reste Ta Grande Soeur Shirt there are inherent problems with most animal models. There are several limitations.
Petit Frère Même Si Tu Es Plus Grand Que Moi N’oublie Pas Je Reste Ta Grande Soeur Shirt is available in all styles
Which is why it continues to be important to use all available data. We design out studies in human in vitro cell models, human organoid cultures, human tissue samples, AND animal models. We have been searching for replacements for the year. Ever since I begin biomedical research as a young graduate student, we have been trying to reduce the amount of whole animal research. We have again used every conceivable idea available.
Petit Frère Même Si Tu Es Plus Grand Que Moi N’oublie Pas Je Reste Ta Grande Soeur Shirt, Hoodie and Sweater designed by Beauty T-shirts
They all fall short of animal experiments. My problem is that news organizations pick up research like this report it as if ready for prime time in the present. It is not. We use microfluidic devices like this all the time in our research. For example, mouse models are the notoriously poor recapitalization of type 2 diabetes. If you actually read this you would know it would never be able to replace it. But can reduce animals needed in preclinical trials.
All this is done because to try it get the best data possible before going to human testing. Yes. There are times when you fail because your models are not good mimics… I am not saying these new on systems should not be used. They will become an important part of our research process. There is not a viable option for Petit Frère Même Si Tu Es Plus Grand Que Moi N’oublie Pas Je Reste Ta Grande Soeur Shirt testing the basic safety of lead compounds or experimental data confirmation that is as effective as whole organism models.