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Ventricular hypertrophy was not observed with aging and the Nebraska Strong Shirt structural composition of the myocardium was modestly affected. Alterations in the myocyte compartment were identified in aged dogs, and these factors negatively interfere with the contractile reserve typical of the young heart. The duration of the action potential is prolonged in old cardiomyocytes contributing to the slower electrical recovery of the myocardium. Coronary flow at low LAD pressure doubled during tachycardia when intracoronary adenosine was added.
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Chronically instrumented swine were exercised on a treadmill up to 85% of maximum heart rate. Under resting conditions, adenosine receptor blockade channel blockade glibenclamide produced similar decreases in myocardial supply in normal and MI swine for clot dissolution and mechanical clot removal. Use of tPA is greatly limited by the relatively short time frame in which it can be safely administered and mechanical retrieval has similar limitations. Currently, much effort is being directed.
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