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When the first transplant using a donated Island Hoppers Shirt windpipe coated with the patient’s own stem cells was carried out in 2008 it made global headlines. It was thought that stripping the donor’s cells from the surface of the trachea and seeding it with the patient’s own stem cells created a new organ that would be like the patient’s own tissue. No anti-rejection drugs would be needed for the “tissue-engineered” trachea. where Macchiarini was also made an honorary professor.
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The operation was carried out by Italian surgeon Paolo Macchiarini with the help of Martin Birchall, then a surgeon at Bristol University. The recipient was 30-year-old Claudia Castillo, who had tuberculosis in part of her windpipe that leads to the lungs – the bronchus. Her case was written up in The Lancet. Five months after she’d had her operation, she was reported to be in perfect health. Stockholm’s prestigious Karolinska Institute.
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The 3-part documentary series “The Experiment” is broadcasted on SVT. The documentary, which closely follows Paolo Macchiarini, shows how patients have suffered and died in connection with failed transplant surgery involving artificial tracheas, and raises numerous issues concerning care and research ethics. The fierce public response to the series causes a crisis of confidence in KI. Birchall, for his part, moved to University College London (UCL).
An external inquiry is launched by the Karolinska Institutet University Board into Karolinska Institutet’s handling of the entire case, from Paolo Macchiarini’s recruitment in 2010 to the present. It is to be led by the lawyer Sten Heckscher. The University Board also decides to give Vice-Chancellor Anders Hamsten their Island Hoppers Shirt continuing confidence for the duration of the inquiry. Indeed, soon the university that hands out the Nobel Prize for medicine.