We report for the first time that oscillatory airway smooth muscle mechanics is governed predominantly by one class of nonlinear mechanosensitive energy loss element and one class of nonlinear mechanosensitive energy release element with differential mechanosensitivity to oscillatory strain amplitude. Prestrain and I’m A Boy I Just Have Better Hair Than You Shirt cholinergic stimulation synergistically and differentially recruit energy loss and energy release elements. The greater mechanosensitivity of the energy loss.
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Element than the energy release element may explain the bronchodilatory effect of deep inspiration. Detection of early atrophic processes and irreversible adaptation to disuse are of high clinical relevance. With the use of tensiomyography (TMG), we detected early atrophic processes before overt architectural changes, and atrophy can be detected using the imaging technique. Furthermore, TMG detected irreversible changes in biceps femoris contraction time.
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Immune system impairment may inhibit future human space exploration missions to Mars. Natural killer (NK) cells are key components of immunity and vital for tumor surveillance and the prevention of latent virus reactivation. We report that NK cell function is impaired in astronauts during an ~6-mo orbital space mission compared with preflight levels and ground-based controls. Declines in NK cell function were more marked in first-time “rookie” fliers. Countermeasures are needed.
To preserve NK cell-mediated immunity during spaceflight. In this work, systemic and continuous delivery of the “soluble” or “cleaved” form of the FGF23 coreceptor α-Klotho (cKL) via an adeno-associated virus to a rodent model of diabetic nephropathy (DN), the db/db uninephrectomized mouse, normalized blood phosphate levels regardless of I’m A Boy I Just Have Better Hair Than You Shirt disease severity. This work supports the concept that targeting cKL-affected pathways could provide future therapeutic avenues.